Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation

Clostridium difficile, the causative agent of antibiotic-associated colitis, mediates inflammatory diarrhea by releasing toxin A, a potent 308-kDa enterotoxin. Toxin A-induced inflammatory diarrhea involves many steps, including mucosal release of substance P (SP) corticotropin-releasing hormone (CR...

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Bibliographic Details
Main Authors: Anton, Pauline M., Gay, Jerome, Mykoniatis, Andreas, Pan, Amy, O'Brien, Michael, Brown, Daniel, Karalis, Katia, Pothoulakis, Charalabos
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC420423/
https://ncbi.nlm.nih.gov/pubmed/15159534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402693101
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