Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation

Clostridium difficile, the causative agent of antibiotic-associated colitis, mediates inflammatory diarrhea by releasing toxin A, a potent 308-kDa enterotoxin. Toxin A-induced inflammatory diarrhea involves many steps, including mucosal release of substance P (SP) corticotropin-releasing hormone (CR...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Anton, Pauline M., Gay, Jerome, Mykoniatis, Andreas, Pan, Amy, O'Brien, Michael, Brown, Daniel, Karalis, Katia, Pothoulakis, Charalabos
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC420423/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15159534/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0402693101
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