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Corticotropin-Releasing Hormone Deficiency Is Associated with Reduced Local Inflammation in a Mouse Model of Experimental Colitis

CRH, the hypothalamic component of the hypothalamic-pituitary adrenal axis, attenuates inflammation through stimulation of glucocorticoid release, whereas peripherally expressed CRH acts as a proinflammatory mediator. CRH is expressed in the intestine and up-regulated in patients with ulcerative col...

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Detalhes bibliográficos
Main Authors: Gay, Jérôme, Kokkotou, Efi, O'Brien, Michael, Pothoulakis, Charalabos, Karalis, Katia P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453096/
https://ncbi.nlm.nih.gov/pubmed/18403481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-1703
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