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WAVE2 Regulates High-Affinity Integrin Binding by Recruiting Vinculin and Talin to the Immunological Synapse

T-cell-receptor (TCR)-mediated integrin activation is required for T-cell-antigen-presenting cell conjugation and adhesion to extracellular matrix components. While it has been demonstrated that the actin cytoskeleton and its regulators play an essential role in this process, no mechanism has been e...

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Detalhes bibliográficos
Main Authors: Nolz, Jeffrey C., Medeiros, Ricardo B., Mitchell, Jason S., Zhu, Peimin, Freedman, Bruce D., Shimizu, Yoji, Billadeau, Daniel D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952166/
https://ncbi.nlm.nih.gov/pubmed/17591693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00136-07
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