Factor H Binding to PspC of Streptococcus pneumoniae Increases Adherence to Human Cell Lines In Vitro and Enhances Invasion of Mouse Lungs In Vivo

Pneumococcal surface protein C (PspC) binds to both human secretory immunoglobulin A (sIgA) and complement factor H (FH). FH, a regulator of the alternative pathway of complement, can also mediate adherence of different host cells. Since PspC contributes to adherence and invasion of host cells, we h...

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Detalhes bibliográficos
Main Authors: Quin, Lisa R., Onwubiko, Chinwendu, Moore, Quincy C., Mills, Megumi Fujioka, McDaniel, Larry S., Carmicle, Stephanie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952001/
https://ncbi.nlm.nih.gov/pubmed/17562771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00474-07
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