The Effects of PspC on Complement-Mediated Immunity to Streptococcus pneumoniae Vary with Strain Background and Capsular Serotype

Streptococcus pneumoniae may evade complement activity by binding of factor H (FH), a negative regulator of the alternative pathway, to the surface protein PspC. However, existing data on the effects of FH binding to PspC on complement activity are conflicting, and there is also considerable allelic...

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Bibliographische Detailangaben
Hauptverfasser: Yuste, Jose, Khandavilli, Suneeta, Ansari, Naadir, Muttardi, Kairya, Ismail, Laura, Hyams, C., Weiser, Jeffrey, Mitchell, Timothy, Brown, Jeremy S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Host Response and Inflammation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798213/
https://ncbi.nlm.nih.gov/pubmed/19884335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00541-09
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