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Pneumolysin, PspA, and PspC Contribute to Pneumococcal Evasion of Early Innate Immune Responses during Bacteremia in Mice

The pneumococcal virulence factors include capsule, PspA, PspC, and Ply. Cytometric analysis demonstrated that the greatest levels of C3 deposition were on a Δply PspA(−) PspC(−) mutant. Also, Ply, PspA, and PspC expression resulted in C3 degradation in vitro and in vivo. Finally, blood clearance as...

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Bibliografske podrobnosti
Main Authors: Quin, Lisa R., Moore, Quincy C., McDaniel, Larry S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865685/
https://ncbi.nlm.nih.gov/pubmed/17220305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01727-06
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