PspC, a Pneumococcal Surface Protein, Binds Human Factor H

PspC was found to bind human complement factor H (FH) by Western blot analysis of D39 (pspC(+)) and an isogenic mutant TRE108 (pspC). We confirmed that PspA does not bind FH, while purified PspC binds FH very strongly. The binding of FH to exponentially growing pneumococci varied among different iso...

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Bibliographic Details
Main Authors: Dave, Sandhya, Brooks-Walter, Alexis, Pangburn, Michael K., McDaniel, Larry S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC98306/
https://ncbi.nlm.nih.gov/pubmed/11292770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.5.3435-3437.2001
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