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Antibody Recognition of Cell Surface-Associated NS1 Triggers Fc-γ Receptor-Mediated Phagocytosis and Clearance of West Nile Virus-Infected Cells

Previous studies have suggested that monoclonal antibodies (MAbs) to flavivirus nonstructural protein-1 (NS-1) protect against infection in mice through an Fc-γ receptor-dependent pathway. To identify a specific mechanism, we evaluated the protective activity of anti-NS1 MAbs to WNV using mice and c...

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Autors principals: Chung, Kyung Min, Thompson, Bruce S., Fremont, Daved H., Diamond, Michael S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951387/
https://ncbi.nlm.nih.gov/pubmed/17582005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00879-07
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