Pattern Recognition Receptor MDA5 Modulates CD8(+) T Cell-Dependent Clearance of West Nile Virus from the Central Nervous System

Many viruses induce type I interferon responses by activating cytoplasmic RNA sensors, including the RIG-I-like receptors (RLRs). Although two members of the RLR family, RIG-I and MDA5, have been implicated in host control of virus infection, the relative role of each RLR in restricting pathogenesis...

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Autores principales: Lazear, Helen M., Pinto, Amelia K., Ramos, Hilario J., Vick, Sarah C., Shrestha, Bimmi, Suthar, Mehul S., Gale, Michael, Diamond, Michael S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807324/
https://ncbi.nlm.nih.gov/pubmed/23966390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01403-13
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