Interferon Regulatory Factor 5-Dependent Immune Responses in the Draining Lymph Node Protect against West Nile Virus Infection

Upon activation of Toll-like and RIG-I-like receptor signaling pathways, the transcription factor IRF5 translocates to the nucleus and induces antiviral immune programs. The recent discovery of a homozygous mutation in the immunoregulatory gene guanine exchange factor dedicator of cytokinesis 2 (Doc...

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Detalhes bibliográficos
Main Authors: Thackray, Larissa B., Shrestha, Bimmi, Richner, Justin M., Miner, Jonathan J., Pinto, Amelia K., Lazear, Helen M., Gale, Michael, Diamond, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178807/
https://ncbi.nlm.nih.gov/pubmed/25031348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01545-14
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