A Naturally Occurring Splice Variant of CXCL12/Stromal Cell-Derived Factor 1 Is a Potent Human Immunodeficiency Virus Type 1 Inhibitor with Weak Chemotaxis and Cell Survival Activities

CXCL12/stromal cell-derived factor 1 is a member of the CXC family of chemokines that plays an important role in hematopoiesis and signals through CXCR4 and CXCR7. Two splice variants of human CXCL12 (CXCL12α and CXCL12β) induce chemotaxis of CXCR4(+) cells and inhibit X4 infection. Recent studies d...

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Bibliographic Details
Main Authors: Altenburg, Jeffrey D., Broxmeyer, Hal E., Jin, Qingwen, Cooper, Scott, Basu, Sunanda, Alkhatib, Ghalib
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Cellular Response to Infection
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951332/
https://ncbi.nlm.nih.gov/pubmed/17507482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00268-07
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