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Transforming growth factor-β1 modulates responses of CD34(+) cord blood cells to stromal cell-derived factor-1/CXCL12

Disruption of stromal cell-derived factor-1 (SDF-1/CXCL12 [CXC chemokine ligand 12]) interaction leads to mobilization of stem/progenitor cells from bone marrow to circulation. However, prolonged exposure of CD34(+) cells to SDF-1 desensitizes them to SDF-1. So how do cells remain responsive to SDF-...

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Detalhes bibliográficos
Main Authors: Basu, Sunanda, Broxmeyer, Hal E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895172/
https://ncbi.nlm.nih.gov/pubmed/15797995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-10-4145
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