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A Naturally Occurring Splice Variant of CXCL12/Stromal Cell-Derived Factor 1 Is a Potent Human Immunodeficiency Virus Type 1 Inhibitor with Weak Chemotaxis and Cell Survival Activities

CXCL12/stromal cell-derived factor 1 is a member of the CXC family of chemokines that plays an important role in hematopoiesis and signals through CXCR4 and CXCR7. Two splice variants of human CXCL12 (CXCL12α and CXCL12β) induce chemotaxis of CXCR4(+) cells and inhibit X4 infection. Recent studies d...

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Detalhes bibliográficos
Main Authors: Altenburg, Jeffrey D., Broxmeyer, Hal E., Jin, Qingwen, Cooper, Scott, Basu, Sunanda, Alkhatib, Ghalib
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951332/
https://ncbi.nlm.nih.gov/pubmed/17507482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00268-07
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