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The Potent Anti-HIV Activity of CXCL12γ Correlates with Efficient CXCR4 Binding and Internalization

We previously demonstrated that the naturally occurring splice variant stromal cell-derived factor 1γ/CXCL12γ is the most potent CXCL12 isoform in blocking X4 HIV-1, with weak chemotactic activity. A conserved BBXB domain (B for basic and X for any residue) located in the N terminus ((24)KHLK(27)) i...

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Detalhes bibliográficos
Main Authors: Altenburg, Jeffrey D., Jin, Qingwen, Alkhatib, Bashar, Alkhatib, Ghalib
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820898/
https://ncbi.nlm.nih.gov/pubmed/20015992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00342-09
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