Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2

Dichloroacetate (DCA) is a promising anticancer and antidiabetic compound targeting the mitochondrial pyruvate dehydrogenase kinase (PDHK). This study was undertaken in order to map the DCA-binding site of PDHK2. Here, we present evidence that R114, S83, I157 and, to some extent, H115 are essential...

Full description

Saved in:
Bibliographic Details
Main Authors: Klyuyeva, Alla, Tuganova, Alina, Popov, Kirill M.
Format: Artigo
Language:Inglês
Published: 2007
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950259/
https://ncbi.nlm.nih.gov/pubmed/17544412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.05.052
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items