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Structural and Functional Insights into the Molecular Mechanisms Responsible for the Regulation of Pyruvate Dehydrogenase Kinase 2

PDHK2 is a mitochondrial protein kinase that phosphorylates pyruvate dehydrogenase complex, thereby down-regulating the oxidation of pyruvate. Here, we present the crystal structure of PDHK2 bound to the inner lipoyl-bearing domain of dihydrolipoamide transacetylase (L2) determined with or without b...

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書誌詳細
主要な著者: Green, Todd, Grigorian, Alexei, Klyuyeva, Alla, Tuganova, Alina, Luo, Ming, Popov, Kirill M.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2414299/
https://ncbi.nlm.nih.gov/pubmed/18387944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800311200
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