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Allosteric Coupling in Pyruvate Dehydrogenase Kinase 2

Mitochondrial pyruvate dehydrogenase kinase 2 (PDHK2) phosphorylates the pyruvate dehydrogenase multienzyme complex (PDC) and thereby controls the rate of oxidative decarboxylation of pyruvate. The activity of PDHK2 is regulated by a variety of metabolites such as pyruvate, NAD(+), NADH, CoA, and ac...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Klyuyeva, Alla, Tuganova, Alina, Popov, Kirill M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568900/
https://ncbi.nlm.nih.gov/pubmed/18627174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800631h
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