Φορτώνει......
Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2
Dichloroacetate (DCA) is a promising anticancer and antidiabetic compound targeting the mitochondrial pyruvate dehydrogenase kinase (PDHK). This study was undertaken in order to map the DCA-binding site of PDHK2. Here, we present evidence that R114, S83, I157 and, to some extent, H115 are essential...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2007
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1950259/ https://ncbi.nlm.nih.gov/pubmed/17544412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.05.052 |
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