Toll-Like Receptor 2 Impairs Host Defense in Gram-Negative Sepsis Caused by Burkholderia pseudomallei (Melioidosis)

BACKGROUND: Toll-like receptors (TLRs) are essential in host defense against pathogens by virtue of their capacity to detect microbes and initiate the immune response. TLR2 is seen as the most important receptor for gram-positive bacteria, while TLR4 is regarded as the gram-negative TLR. Melioidosis...

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Autors principals: Wiersinga, W. Joost, Wieland, Catharina W, Dessing, Mark C, Chantratita, Narisara, Cheng, Allen C, Limmathurotsakul, Direk, Chierakul, Wirongrong, Leendertse, Masja, Florquin, Sandrine, de Vos, Alex F, White, Nicholas, Dondorp, Arjen M, Day, Nicholas P, Peacock, Sharon J, van der Poll, Tom
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2007
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950213/
https://ncbi.nlm.nih.gov/pubmed/17676990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0040248
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