Toll-Like Receptor 2 Impairs Host Defense in Gram-Negative Sepsis Caused by Burkholderia pseudomallei (Melioidosis)

BACKGROUND: Toll-like receptors (TLRs) are essential in host defense against pathogens by virtue of their capacity to detect microbes and initiate the immune response. TLR2 is seen as the most important receptor for gram-positive bacteria, while TLR4 is regarded as the gram-negative TLR. Melioidosis...

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Autori principali: Wiersinga, W. Joost, Wieland, Catharina W, Dessing, Mark C, Chantratita, Narisara, Cheng, Allen C, Limmathurotsakul, Direk, Chierakul, Wirongrong, Leendertse, Masja, Florquin, Sandrine, de Vos, Alex F, White, Nicholas, Dondorp, Arjen M, Day, Nicholas P, Peacock, Sharon J, van der Poll, Tom
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950213/
https://ncbi.nlm.nih.gov/pubmed/17676990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0040248
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