Wide-Scale Analysis of Human Functional Transcription Factor Binding Reveals a Strong Bias towards the Transcription Start Site

BACKGROUND: Transcription factors (TF) regulate expression by binding to specific DNA sequences. A binding event is functional when it affects gene expression. Functionality of a binding site is reflected in conservation of the binding sequence during evolution and in over represented binding in gen...

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Autori principali: Tabach, Yuval, Brosh, Ran, Buganim, Yossi, Reiner, Anat, Zuk, Or, Yitzhaky, Assif, Koudritsky, Mark, Rotter, Varda, Domany, Eytan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950076/
https://ncbi.nlm.nih.gov/pubmed/17726537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000807
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