Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47(null) cells

Macrophages recognize CD47 as a marker of “self” and phagocytose CD47(null) hematopoietic cells. Using CD47 chimera models, here, we show that the phagocytic activity of macrophages against CD47(null) hematopoietic cells is conferred by CD47 expression on nonhematopoietic cells, and this “education”...

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Bibliographic Details
Main Authors: Wang, Hui, Madariaga, Maria Lucia, Wang, Shumei, Van Rooijen, Nico, Oldenborg, Per-Arne, Yang, Yong-Guang
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1949343/
https://ncbi.nlm.nih.gov/pubmed/17699632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702881104
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