Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47(null) cells

Macrophages recognize CD47 as a marker of “self” and phagocytose CD47(null) hematopoietic cells. Using CD47 chimera models, here, we show that the phagocytic activity of macrophages against CD47(null) hematopoietic cells is conferred by CD47 expression on nonhematopoietic cells, and this “education”...

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Autors principals: Wang, Hui, Madariaga, Maria Lucia, Wang, Shumei, Van Rooijen, Nico, Oldenborg, Per-Arne, Yang, Yong-Guang
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1949343/
https://ncbi.nlm.nih.gov/pubmed/17699632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702881104
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