Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47(null) cells

Macrophages recognize CD47 as a marker of “self” and phagocytose CD47(null) hematopoietic cells. Using CD47 chimera models, here, we show that the phagocytic activity of macrophages against CD47(null) hematopoietic cells is conferred by CD47 expression on nonhematopoietic cells, and this “education”...

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Библиографические подробности
Главные авторы: Wang, Hui, Madariaga, Maria Lucia, Wang, Shumei, Van Rooijen, Nico, Oldenborg, Per-Arne, Yang, Yong-Guang
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2007
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1949343/
https://ncbi.nlm.nih.gov/pubmed/17699632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702881104
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