Engineering Small Molecule Specificity in Nearly Identical Cellular Environments

Methotrexate (MTX), an inhibitor of dihydrofolate reductase, was tethered to an FKBP12 ligand (SLF), and the resulting bifunctional molecule (MTXSLF) potently inhibits either enzyme but not both simultaneously. MTXSLF is cytotoxic to fibroblasts derived from FKBP12-null mice but is detoxified 40-fol...

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Main Authors: Sellmyer, Mark A., Stankunas, Kryn, Briesewitz, Roger, Crabtree, Gerald R., Wandless, Thomas J.
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1949043/
https://ncbi.nlm.nih.gov/pubmed/17383876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.03.012
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