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Engineering Small Molecule Specificity in Nearly Identical Cellular Environments
Methotrexate (MTX), an inhibitor of dihydrofolate reductase, was tethered to an FKBP12 ligand (SLF), and the resulting bifunctional molecule (MTXSLF) potently inhibits either enzyme but not both simultaneously. MTXSLF is cytotoxic to fibroblasts derived from FKBP12-null mice but is detoxified 40-fol...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1949043/ https://ncbi.nlm.nih.gov/pubmed/17383876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.03.012 |
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