Dynamic remodelling of human 7SK snRNP controls the nuclear level of active P-TEFb

The 7SK small nuclear RNA (snRNA) regulates RNA polymerase II transcription elongation by controlling the protein kinase activity of the positive transcription elongation factor b (P-TEFb). In cooperation with HEXIM1, the 7SK snRNA sequesters P-TEFb into the kinase-inactive 7SK/HEXIM1/P-TEFb small n...

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Bibliographic Details
Main Authors: Van Herreweghe, Elodie, Egloff, Sylvain, Goiffon, Isabelle, Jády, Beáta E, Froment, Carine, Monsarrat, Bernard, Kiss, Tamás
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1949012/
https://ncbi.nlm.nih.gov/pubmed/17611602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601783
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