4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

TRPA1 is an excitatory ion channel expressed by a subpopulation of primary afferent somatosensory neurons that contain substance P and calcitonin gene-related peptide. Environmental irritants such as mustard oil, allicin, and acrolein activate TRPA1, causing acute pain, neuropeptide release, and neu...

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Bibliografiske detaljer
Main Authors: Trevisani, Marcello, Siemens, Jan, Materazzi, Serena, Bautista, Diana M., Nassini, Romina, Campi, Barbara, Imamachi, Noritaka, Andrè, Eunice, Patacchini, Riccardo, Cottrell, Graeme S., Gatti, Raffaele, Basbaum, Allan I., Bunnett, Nigel W., Julius, David, Geppetti, Pierangelo
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948902/
https://ncbi.nlm.nih.gov/pubmed/17684094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705923104
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