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Protein Kinase C-α and ERK1/2 Mediate Mitochondrial Dysfunction, Decreases in Active Na(+) Transport, and Cisplatin-induced Apoptosis in Renal Cells
Initiation of apoptosis by many agents is preceded by mitochondrial dysfunction and depolarization of the mitochondrial inner membrane. Here we demonstrate that, in renal proximal tubular cells (RPTC), cisplatin induces mitochondrial dysfunction associated with hyperpolarization of the mitochondrial...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2002
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1948818/ https://ncbi.nlm.nih.gov/pubmed/12218054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M206373200 |
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