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Protein Kinase C-α and ERK1/2 Mediate Mitochondrial Dysfunction, Decreases in Active Na(+) Transport, and Cisplatin-induced Apoptosis in Renal Cells

Initiation of apoptosis by many agents is preceded by mitochondrial dysfunction and depolarization of the mitochondrial inner membrane. Here we demonstrate that, in renal proximal tubular cells (RPTC), cisplatin induces mitochondrial dysfunction associated with hyperpolarization of the mitochondrial...

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書誌詳細
第一著者: Nowak, Grażyna
フォーマット: Artigo
言語:Inglês
出版事項: 2002
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948818/
https://ncbi.nlm.nih.gov/pubmed/12218054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M206373200
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