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NADPH Binding to β-Subunit Regulates Inactivation of Voltage-Gated K(+) Channels

Ancillary β-subunits regulate the voltage-dependence and the kinetics of Kv currents. The Kvβ proteins bind pyridine nucleotides with high affinity but the role of cofactor binding in regulating Kv currents remains unclear. We found that recombinant rat Kvβ1.3 binds NADPH (K(d) = 1.8±0.02μM) and NAD...

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Detalles Bibliográficos
Main Authors: Tipparaju, Srinivas M., Liu, Si-Qi, Barski, Oleg, Bhatnagar, Aruni
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948100/
https://ncbi.nlm.nih.gov/pubmed/17540341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.05.102
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