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NADPH Binding to β-Subunit Regulates Inactivation of Voltage-Gated K(+) Channels
Ancillary β-subunits regulate the voltage-dependence and the kinetics of Kv currents. The Kvβ proteins bind pyridine nucleotides with high affinity but the role of cofactor binding in regulating Kv currents remains unclear. We found that recombinant rat Kvβ1.3 binds NADPH (K(d) = 1.8±0.02μM) and NAD...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1948100/ https://ncbi.nlm.nih.gov/pubmed/17540341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.05.102 |
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