NADPH Binding to β-Subunit Regulates Inactivation of Voltage-Gated K(+) Channels

Ancillary β-subunits regulate the voltage-dependence and the kinetics of Kv currents. The Kvβ proteins bind pyridine nucleotides with high affinity but the role of cofactor binding in regulating Kv currents remains unclear. We found that recombinant rat Kvβ1.3 binds NADPH (K(d) = 1.8±0.02μM) and NAD...

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Bibliographic Details
Main Authors:	Tipparaju, Srinivas M., Liu, Si-Qi, Barski, Oleg, Bhatnagar, Aruni
Format:	Artigo
Language:	Inglês
Published:	2007
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC1948100/ https://ncbi.nlm.nih.gov/pubmed/17540341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.05.102
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NADPH Binding to β-Subunit Regulates Inactivation of Voltage-Gated K(+) Channels

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