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R-92L and R-92W Mutations in Cardiac Troponin T Lead to Distinct Energetic Phenotypes in Intact Mouse Hearts
It is now known that the flexibility of the troponin T (TnT) tail determines thin filament conformation and hence cross-bridge cycling properties, expanding the classic structural role of TnT to a dynamic role regulating sarcomere function. Here, using transgenic mice bearing R-92W and R-92L missens...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1948064/ https://ncbi.nlm.nih.gov/pubmed/17526570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.107557 |
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