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Myosin-driven rescue of contractile reserve and energetics in mouse hearts bearing familial hypertrophic cardiomyopathy-associated mutant troponin T is mutation-specific

The thin filament protein troponin T (TnT) is a regulator of sarcomere function. Whole heart energetics and contractile reserve are compromised in transgenic mice bearing missense mutations at R92 within the tropomyosin-binding domain of cTnT, despite being distal to the ATP hydrolysis domain of myo...

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Autori principali: He, Huamei, Hoyer, Kirsten, Tao, Hai, Rice, Ronald, Jimenez, Jesus, Tardiff, Jil C, Ingwall, Joanne S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3515825/
https://ncbi.nlm.nih.gov/pubmed/22907055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.234252
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