Decreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin T

The thin filament protein cardiac troponin T (cTnT) is an important regulator of myofilament activation. Here we report a significant change in cardiac energetics in transgenic mice bearing the missense mutation R92Q within the tropomyosin-binding domain of cTnT, a mutation associated with a clinica...

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Bibliographic Details
Main Authors: Javadpour, Maryam M., Tardiff, Jil C., Pinz, Ilka, Ingwall, Joanne S.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2003
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC182182/
https://ncbi.nlm.nih.gov/pubmed/12952925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200315967
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