R-92L and R-92W Mutations in Cardiac Troponin T Lead to Distinct Energetic Phenotypes in Intact Mouse Hearts

It is now known that the flexibility of the troponin T (TnT) tail determines thin filament conformation and hence cross-bridge cycling properties, expanding the classic structural role of TnT to a dynamic role regulating sarcomere function. Here, using transgenic mice bearing R-92W and R-92L missens...

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Detalles Bibliográficos
Autores principales: He, Huamei, Javadpour, Maryam M., Latif, Farhana, Tardiff, Jil C., Ingwall, Joanne S.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2007
Materias:
Bioenergetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948064/
https://ncbi.nlm.nih.gov/pubmed/17526570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.107557
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