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Charge Immobilization of Skeletal Muscle Na(+) Channels: Role of Residues in the Inactivation Linker

We investigated structural determinants of fast inactivation and deactivation in sodium channels by comparing ionic flux and charge movement in skeletal muscle channels, using mutations of DIII-DIV linker charges. Charge altering and substituting mutations at K-1317, K-1318 depolarized the g(V) curv...

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Main Authors: Groome, James R., Dice, Margaret C., Fujimoto, Esther, Ruben, Peter C.
格式: Artigo
語言:Inglês
出版: The Biophysical Society 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948039/
https://ncbi.nlm.nih.gov/pubmed/17513361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.102079
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