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Charge Immobilization of Skeletal Muscle Na(+) Channels: Role of Residues in the Inactivation Linker
We investigated structural determinants of fast inactivation and deactivation in sodium channels by comparing ionic flux and charge movement in skeletal muscle channels, using mutations of DIII-DIV linker charges. Charge altering and substituting mutations at K-1317, K-1318 depolarized the g(V) curv...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Biophysical Society
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1948039/ https://ncbi.nlm.nih.gov/pubmed/17513361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.102079 |
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