Charge Immobilization of Skeletal Muscle Na(+) Channels: Role of Residues in the Inactivation Linker

We investigated structural determinants of fast inactivation and deactivation in sodium channels by comparing ionic flux and charge movement in skeletal muscle channels, using mutations of DIII-DIV linker charges. Charge altering and substituting mutations at K-1317, K-1318 depolarized the g(V) curv...

Full description

Saved in:
Bibliographic Details
Main Authors: Groome, James R., Dice, Margaret C., Fujimoto, Esther, Ruben, Peter C.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2007
Subjects:
Channels, Receptors, and Electrical Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948039/
https://ncbi.nlm.nih.gov/pubmed/17513361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.102079
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items