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Exploring the Energy Landscape of Protein Folding using Replica-Exchange and Conventional Molecular Dynamics Simulations

Two independent replica-exchange molecular dynamics (REMD) simulations with an explicit water model were performed of the Trp-cage mini-protein. In the first REMD simulation, the replicas started from the native conformation, while in the second they started from a nonnative conformation. Initially,...

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Autori principali: Beck, David A. C., White, George W. N., Daggett, Valerie
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1945213/
https://ncbi.nlm.nih.gov/pubmed/17113307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2006.10.002
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