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C. elegans CUL-4 prevents re-replication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathway

Genome stability requires that genomic DNA is replicated only once per cell cycle. The replication licensing system ensures that the formation of pre-replicative complexes is temporally separated from the initiation of DNA replication [1-4]. The replication licensing factors Cdc6 and Cdt1 are requir...

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Detalhes bibliográficos
Main Authors: Kim, Jihyun, Feng, Hui, Kipreos, Edward T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1945017/
https://ncbi.nlm.nih.gov/pubmed/17509881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2007.04.055
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