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LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease
Liver receptor homolog-1 (LRH-1) is a nuclear receptor involved in intestinal lipid homeostasis and cell proliferation. Here we show that haploinsufficiency of LRH-1 predisposes mice to the development of intestinal inflammation. Besides the increased inflammatory response, LRH-1 heterozygous mice e...
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1941823/ https://ncbi.nlm.nih.gov/pubmed/17670946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702440104 |
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