LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease

Liver receptor homolog-1 (LRH-1) is a nuclear receptor involved in intestinal lipid homeostasis and cell proliferation. Here we show that haploinsufficiency of LRH-1 predisposes mice to the development of intestinal inflammation. Besides the increased inflammatory response, LRH-1 heterozygous mice e...

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Autors principals: Coste, Agnes, Dubuquoy, Laurent, Barnouin, Romain, Annicotte, Jean-Sebastien, Magnier, Benjamin, Notti, Mario, Corazza, Nadia, Antal, Maria Cristina, Metzger, Daniel, Desreumaux, Pierre, Brunner, Thomas, Auwerx, Johan, Schoonjans, Kristina
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1941823/
https://ncbi.nlm.nih.gov/pubmed/17670946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702440104
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