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INTERACTIONS OF HUMAN O(6)-ALKYLGUANINE-DNA ALKYLTRANSFERASE (AGT) WITH SHORT SINGLE-STRANDED DNAS
The O(6)-alkylguanine-DNA alkyltransferase (AGT) repairs O(6)-alkylguanine and O(4)-alkylthymine adducts in single-stranded and duplex DNAs. Here we characterize the binding of AGT to single-stranded DNAs ranging in length from 5 to 78 nt. Binding is moderately cooperative (37.9 ± 3.0 ≤ ω ≤ 89.8 ± 8...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1941669/ https://ncbi.nlm.nih.gov/pubmed/17138560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M608876200 |
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