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MUTATIONS THAT PROBE THE COOPERATIVE ASSEMBLY OF O(6)-ALKYLGUANINE-DNA ALKYLTRANSFERASE (AGT) COMPLEXES
O(6)-alkylguanine-DNA alkyltransferase (AGT) repairs mutagenic O(6)-alkylguanine and O(4)-alkylthymine adducts present in DNA that has been exposed to alkylating agents. AGT binds DNA cooperatively and models of cooperative complexes predict that residues 1–7 of one protein molecule and 163–169 of a...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3051037/ https://ncbi.nlm.nih.gov/pubmed/21226457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101970d |
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