Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers

Ras has achieved notoriety as an oncogene aberrantly activated in multiple human tumors. Approximately 30% of all human tumors express an oncogenic form of this GTPase that is locked in an active conformation as a result of being insensitive to Ras GTPase-activating proteins (GAPs), proteins that no...

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Autors principals: Jin, Hongchuan, Wang, Xian, Ying, Jianming, Wong, Ada H. Y., Cui, Yan, Srivastava, Gopesh, Shen, Zhong-Ying, Li, En-Min, Zhang, Qian, Jin, Jie, Kupzig, Sabine, Chan, Anthony T. C., Cullen, Peter J., Tao, Qian
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1941473/
https://ncbi.nlm.nih.gov/pubmed/17640920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700153104
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