Gene therapy with a single chain interleukin 12 fusion protein induces T cell-dependent protective immunity in a syngeneic model of murine neuroblastoma

A major goal of tumor immunotherapy is the effective eradication of established metastases associated with the induction of a T cell-mediated protective immunity. We achieved this in a poorly immunogenic murine neuroblastoma model by gene therapy with a single chain interleukin 12 (scIL-12) fusion p...

Full description

Saved in:
Bibliographic Details
Main Authors: Lode, Holger N., Dreier, Torsten, Xiang, Rong, Varki, Nissi M., Kang, Angray S., Reisfeld, Ralph A.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1998
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC19380/
https://ncbi.nlm.nih.gov/pubmed/9482910
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items