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Attenuated Salmonella engineered to produce human cytokine LIGHT inhibit tumor growth

Intravenously administered bacteria reportedly accumulate in tumors. Furthermore, systemic administration of attenuated Salmonella typhimurium has little or no significant side-effects in humans. Consequently, we engineered such bacteria to improve their oncolytic activity by stably inserting a gene...

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Detalles Bibliográficos
Main Authors: Loeffler, Markus, Le'Negrate, Gaelle, Krajewska, Maryla, Reed, John C.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1937560/
https://ncbi.nlm.nih.gov/pubmed/17652173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701959104
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