Escherichia coli Cytotoxic Necrotizing Factor 1 Inhibits Intestinal Epithelial Wound Healing In Vitro after Mechanical Injury

Cytotoxic necrotizing factor type 1 (CNF1) from Escherichia coli activates the small GTP-binding proteins of the Rho family (Rho, Rac, and Cdc42) by catalyzing their deamidation at a specific glutamine residue. Since RhoA, Rac, and Cdc42 play a pivotal role in cell migration during the early phase o...

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Bibliographic Details
Main Authors: Brest, Patrick, Turchi, Laurent, Le'Negrate, Gaëlle, Berto, Frédérick, Moreilhon, Chimène, Mari, Bernard, Ponzio, Gilles, Hofman, Paul
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC517525/
https://ncbi.nlm.nih.gov/pubmed/15385472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.10.5733-5740.2004
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