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Attenuated Salmonella engineered to produce human cytokine LIGHT inhibit tumor growth
Intravenously administered bacteria reportedly accumulate in tumors. Furthermore, systemic administration of attenuated Salmonella typhimurium has little or no significant side-effects in humans. Consequently, we engineered such bacteria to improve their oncolytic activity by stably inserting a gene...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1937560/ https://ncbi.nlm.nih.gov/pubmed/17652173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701959104 |
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