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Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-γ-induced class II transactivator

Expansion of the pool of tumor necrosis factor (TNF)-α-producing T cells is instrumental for the bone loss induced by estrogen deficiency, but the responsible mechanism is unknown. Here we show that ovariectomy up-regulates IFN-γ-induced class II transactivator, a multitarget immune modulator, resul...

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Библиографические подробности
Главные авторы: Cenci, Simone, Toraldo, Gianluca, Weitzmann, M. Neale, Roggia, Cristiana, Gao, Yuhao, Qian, Wei Ping, Sierra, Oscar, Pacifici, Roberto
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2003
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC193574/
https://ncbi.nlm.nih.gov/pubmed/12923292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1533207100
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