Up-regulation of TNF-producing T cells in the bone marrow: A key mechanism by which estrogen deficiency induces bone loss in vivo

In vivo studies have shown T cells to be central to the mechanism by which estrogen deficiency induces bone loss, but the mechanism involved remains, in part, undefined. In vitro, T cells from ovariectomized mice produce increased amounts of tumor necrosis factor (TNF), which augments receptor activ...

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Detalhes bibliográficos
Main Authors: Roggia, Cristiana, Gao, Yuhao, Cenci, Simone, Weitzmann, M. Neale, Toraldo, Gianluca, Isaia, Giancarlo, Pacifici, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC61149/
https://ncbi.nlm.nih.gov/pubmed/11717453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.251534698
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