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Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl
Conventional cancer therapies are based on preferential killing of tumor cells by DNA damage. Previous work showed that, for certain cell types, loss of integrin-mediated adhesion decreased the apoptotic response to DNA damage because of decreased p53 levels after detachment from the extracellular m...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC193552/ https://ncbi.nlm.nih.gov/pubmed/12928501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1635435100 |
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